Number of motors/propellers on the frame.
More blades increase thrust at a given diameter but also increase drag, reducing efficiency. Bi-blades are the efficiency standard; tri-blades trade some efficiency for a smoother power band.
Number of LiPo cells in series. Each nominal cell is 3.7 V; full charge is 4.2 V/cell. Higher S count raises voltage, which raises RPM proportionally.