Newborn Hyperbilirubinemia Assessment Calculator

Your details

Postnatal age in hours at the time the bilirubin sample was drawn. Must be between 1 and 336 hours.
hours
Measured total serum bilirubin, in milligrams per deciliter.
mg/dL
Gestational age at birth in completed weeks. This calculator applies to infants 35 weeks or more.
weeks
Risk factors include isoimmune hemolytic disease, G6PD deficiency, asphyxia, significant lethargy, temperature instability, sepsis, acidosis, or albumin below 3.0 g/dL.
Phototherapy thresholdBelow phototherapy threshold
15.5mg/dL

TSB level at which phototherapy is recommended for this infant

Exchange transfusion threshold20.5mg/dL
Escalation-of-care threshold18.5mg/dL
Margin from phototherapy threshold-3.5mg/dL
Risk tierLow
RecommendationTSB is below the phototherapy threshold. Continue routine clinical monitoring.
15.5 mg/dL
Very Low<10Low-Normal10-14Approaching threshold14-17At/above phototherapy threshold17-21Exchange transfusion zone21+

TSB 12.0 mg/dL at 48 h: TSB is below the phototherapy threshold

  • This infant is classified as Low Risk based on gestational age and risk factor status.
  • The measured TSB of 12.0 mg/dL is 3.5 mg/dL below the phototherapy threshold of 15.5 mg/dL.
  • Thresholds are based on the 2022 AAP Clinical Practice Guideline. Clinical judgment, direct bilirubin fraction, and Coombs results should be incorporated alongside these numbers.

Next stepConfirm the result with a clinical assessment. For infants near or above the phototherapy threshold, repeat TSB in 4-6 hours or earlier if clinically indicated.

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