Plasma Volume Calculator

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Adults use the Nadler or weight-based formula. Pediatric patients use age-specific mL/kg factors (100, 85, 75, or 70 mL/kg).
Sex changes the Nadler coefficients and the simple mL/kg factor. The Lemmens-Bernstein-Brodsky equation is not sex-specific.
Nadler is the most widely validated. LBB corrects for obesity. The simple method is a rapid bedside estimate when height is unavailable.
Patient body weight.
kg
Required for the Nadler and Lemmens-Bernstein-Brodsky methods.
cm
The fraction of blood volume occupied by red blood cells, expressed as a percentage. Typical adult ranges: 38-50% for males, 35-47% for females.
%
Plasma VolumeNormal range
2,798mL

Volume of blood plasma = TBV x (1 - Hct)

Total Blood Volume4,824mL
RBC Volume2,026mL
Plasma fraction58%
MethodNadler equation
58% %
Low plasma fraction<45Normal plasma fraction45-65High plasma fraction65+

Estimated plasma volume: 2798 mL

  • Plasma makes up 58.0% of total blood volume (4824 mL), with 2026 mL occupied by red blood cells.
  • Typical adult plasma volume is roughly 2500-3500 mL. Values outside this range may reflect dehydration, overhydration, anemia, or polycythemia.
  • These are estimates for clinical orientation only. Accurate plasma volume measurement requires isotope dilution or dye-dilution techniques.

Next stepIf you suspect clinically significant hypovolemia or hypervolemia, consult a physician for formal blood volume measurement and assessment.

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