▸SAAG is 1.70 g/dL - portal hypertension is likely.
- A SAAG above 1.1 g/dL identifies portal hypertension as the mechanism of ascites with approximately 97% accuracy.
- Common portal hypertensive causes include cirrhosis, alcoholic hepatitis, cardiac ascites, Budd-Chiari syndrome (early), and portal vein thrombosis.
- Ascitic fluid total protein (AFTP) can help narrow the cause further: AFTP below 2.5 g/dL with high SAAG strongly suggests cirrhosis, while AFTP above 2.5 g/dL suggests cardiac or Budd-Chiari origin.
- Both albumin samples must be obtained on the same day - even a 24-hour gap can reduce accuracy because albumin levels fluctuate.
Next stepInitiate sodium restriction (less than 2 g/day) and consider diuretics. Evaluate for the specific cause with liver imaging, echocardiography if cardiac ascites is suspected, and hepatic vein Doppler for Budd-Chiari.