tPA (Alteplase) Stroke Dosing Calculator

Your details

Actual body weight. For patients over 100 kg the total dose is capped at 90 mg.
kg
The 3-hour window has the strongest evidence and FDA approval. The 3-4.5-hour window applies only to eligible patients per AHA/ASA 2019 guidelines.
Standard reconstitution with Sterile Water for Injection gives 1 mg/mL. Some protocols dilute further to 0.5 mg/mL.
Total doseHigh-range dose
67.5mg

0.9 mg/kg, capped at 90 mg

IV bolus (10%)6.8mg
Infusion (90%)60.8mg
Bolus volume6.8mL
Infusion volume60.8mL
Total volume67.5mL
Infusion rate60.8mL/hr
Weight used75kg
Dose cap appliedNo - full weight-based dose used
IV Bolus (mg)6.8
Infusion (mg)60.8

Total alteplase dose: 67.5 mg

  • Dose is 67.5 mg based on 75.0 kg at 0.9 mg/kg.
  • Bolus: 6.8 mg (6.8 mL at 1 mg/mL) pushed IV over 1 minute.
  • Infusion: 60.8 mg (60.8 mL at 1 mg/mL) run at 60.8 mL/hr for 60 minutes.
  • Treatment is within the 3-hour FDA-approved window - the strongest evidence tier.

Next stepVerify patient eligibility, check contraindications, and confirm with institutional pharmacy protocol before administration. Blood pressure must be maintained below 185/110 mmHg prior to and during infusion.

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