Kidney Failure Risk Calculator (KFRE)

Your details

The 4-variable model needs only routine clinic values. The 8-variable model adds four serum labs and is slightly more precise.
US labs report ACR in mg/g; UK and Canadian labs usually use mg/mmol. 1 mg/mmol = 8.84 mg/g.
Patient age in whole years. KFRE was validated in adults.
years
Biological sex assigned at birth, as used in the original KFRE validation cohorts.
Estimated glomerular filtration rate from a CKD-EPI or MDRD creatinine-based equation. KFRE is validated for CKD stages G3-G5 (eGFR 1-60).
mL/min/1.73m²
Urine albumin-to-creatinine ratio. A spot urine sample is acceptable. Higher values indicate greater albuminuria and higher risk.
mg/g
2-year kidney failure riskLow-moderate risk
1.8%

Probability of reaching kidney failure (dialysis or transplant) within 2 years

5-year kidney failure risk6.6%
Risk categoryLow-moderate risk
Nephrology referral indicatorConsider nephrology referral (5-year risk > 5%)
6.6% %
Low<5%Low-moderate5%-10%Moderate10%-20%High20%-40%Very high40%+

6.6% probability of kidney failure within 5 years (low-moderate risk).

  • Your 2-year kidney failure risk is 1.8% and your 5-year risk is 6.6% (low-moderate risk).
  • Guidelines recommend nephrology referral when the 5-year KFRE exceeds 5%. Discuss this result with your care team.

Next stepKFRE is a planning tool, not a diagnosis. Actual progression depends on your underlying kidney disease, blood pressure control, diabetes management, and adherence to therapy. Discuss these results with a nephrologist.

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