Acute pain allows higher single doses. Chronic pain typically uses extended-release or a slow IR titration.
IR is taken every 4-6 hours for acute pain. ER is taken once daily and is reserved for chronic around-the-clock pain.
Patients with creatinine clearance below 30 mL/min require extended dosing intervals and a lower daily maximum for IR. ER is contraindicated.
Severe hepatic impairment (Child-Pugh Class C) limits IR dosing to 50 mg every 12 hours and is a contraindication for ER.
Select the tablet strength you have available to calculate how many tablets equal the recommended starting dose.